TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome is defined as a severe neurological disorder, which is characterized by sudden, repetitive, and involuntary movements as well as vocalizations. Mutations in the SLITRK1 gene is responsible for such syndrome. TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome mostly affects children with the age group between 3 to 9 and it gradually spreads over period. Males are seen to be the most vulnerable to TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome as compared with females. In this syndrome several tics are noticed. Simple tics are described as brief, sudden, and repetitive movements of muscles, whereas other tics include facial grimacing, eye blinking, and shoulder jerking. However, this syndrome is also associated with other neurobehavioral problems such as writing, reading, and OCD. Â
Diagnosis for TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome include several neuroimaging studies such as MRI, CT scan, and EEG and a few blood tests. However, medical professionals often recommend Neroleptics drugs for bettering the situation of the TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome victimized children. Several other medications such as guanfacine and clonidine are also effective in terms of reducing tics severity. Growing number of children worldwide suffering from TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome and rapid consumption of such medicines are a couple of factors driving the global TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment market. Â
Furthermore, medical treatments of TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome also include psychotherapy, behavior, and medication. Non-tic symptoms are mostly treated with selective serotonin reuptake inhibitors. However, depending on the severity of tics, healthcare professionals also prescribe combination drug for TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome. Growing research and development and rising expenditures in healthcare infrastructure worldwide are also providing major impetus to the growth of the global TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment market.
TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome is a severe and rare neurological disorder characterized by stereotyped, repetitive, involuntary movements, and vocalizations. It usually affects children aged between six years and 17 years. A tic is a sudden, no rhythmic motor movement, repetitive or vocalization involving discrete muscle groups. Generally, tics are categorized into simple or complex tics. Simple tics are defined as sudden, brief, repetitive movements of muscles. Others include eye blinking, facial grimacing, head or shoulder jerking, shoulder shrugging, and repetitive throat-clearing. Complex tics are coordinated patterns of movements associated with several muscle groups. Facial grimacing, sniffing or touching objects, bending, twisting, and jumping can be termed as complex tics. Usually, the first symptoms of tics occur in head and neck area and progress to trunk and extremities muscles. TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome is associated with other additional neurobehavioral problems such as inattention, impulsivity (attention deficit hyperactivity disorder-ADHD), problems with reading and writing, and obsessive-compulsive symptoms.
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Health care professionals diagnose TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome based on motor and vocal tics for at least a year. Other neurological or psychiatric conditions including compulsive behaviors in obsessive-compulsive disorder and stereotypic behaviors in autism also help to diagnose TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome. Neuroimaging studies including computerized tomography (CT), magnetic resonance imaging (MRI), electroencephalogram (EEG) scans, and certain blood tests help to diagnose TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome. Neuroleptics is one of the most recommended medications for the treatment of the syndrome. Haloperidol and pimozide are popular medicine for TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome. Other medications such as clonidine and guanfacine can also be useful to reduce tic severity. Increase in research and development as well as health care infrastructure globally drive the TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment market. Rise in medical costs restrain the market in developing countries.
The global TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment market can be segmented based on medical treatment and region. In terms of medical treatment, the market can be categorized into behavior, psychotherapy, and medication. Medicines including fluphenazine, haloperidol (Haldol), and pimozide (Orap) can help control tics in TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome. Non-tic symptoms can be treated with anti-obsessionals such as selective serotonin reuptake inhibitors, or SSRIs or ADHD medication including dextroamphetamine, atomoxetine, and methylphenidate. Depending on the severity, combination drug is also recommended by health care professional for TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome.
Geographically, the global TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment market can be segmented into five major regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. These regions can be further segmented into countries and medical treatment. North America is the leading market for TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment. In terms of revenue, the U.S. holds a major share of the market in North America. The market in Europe is expanding rapidly due to rise in prevalence of TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome in the region. The market in Asia Pacific and Latin America is projected to expand significantly in the near future due to high annual incidence of TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome. Developing economies such as China and India are anticipated to contribute to the growth of the market in Asia Pacific between 2017 and 2025 due to better health care infrastructure, economic growth, increase in the number of insurance payers, growth of the private health care sector, and increase in awareness among people. Brazil and Mexico dominate the TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome market in Latin America. South Africa, Turkey, and other developing countries in Middle East & Africa are the major markets for TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment in this region.
Key players operating in the global TouretteÃÂ¢Ã¢âÂ¬Ã¢âÂ¢s syndrome treatment market are Neurocrine Biosciences, Inc., Novartis AG, Otsuka Pharmaceutical Co., Ltd., Teva Pharmaceuticals USA, Inc., Apotex, Inc., Janssen Pharmaceuticals, Inc., Zydus Pharmaceuticals USA, Inc., Eli Lilly and Company, and Torrent Pharmaceuticals Limited.
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